４－氨基－５－咪唑甲酰胺盐酸盐（１）是重要医药中间体。文献［１］以氰乙酸乙酯（５）为原料，经酯化、氨解和偶联反应制得２－脒基－２－苯偶氮基乙酰胺盐酸盐（２），再还原制得２－脒基－２－甲酰胺基乙酰胺盐酸盐，在此步反应中使用大量无水乙醚和９５％乙醇，然后在１ 4-Amino-5-imidazole carboxamide hydrochloride (1) is an important pharmaceutical intermediate. Literature [1] ethyl cyanoacetate (5) as raw material, esterification, ammonolysis and coupling reaction 2-amidino-2-phenylazo acetamide hydrochloride (2), and then restore the system 2-amidino-2-carboxamidoacetamide hydrochloride, using a large amount of anhydrous ethyl ether and 95% ethanol in this step, then stirring at 1