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系统性红斑狼疮异质性强,诊断尤其是早期诊断难度较大.1971年以来,美国风湿病学学会和国际狼疮研究临床协作组多次推荐的分类标准,也仅为临床表现结合实验室检测的“老式”临床组合,至今也没有发现特异性生物标记物.本文对分类标准的分析,提示未来的研究可能从基因组学和蛋白组学的角度,更加细化分类标准的研究.“,”At the present,systemic lupus erythematosus is a heterogeneous disease in which diagnosis,especially early diagnosis,is always rather difficult.Because of this,the systems of classification criteria for clinical diagnosis,which include recommendations of the American college of rheumatology and the systemic lupus international collaborating clinics,have been utilized since 1971.However,there is still no single biomarker that is pathognomonic for the disease.Currently,the diagnosis still requires “ old-fashioned” clinical acumen with the assistance of standardized clinical and laboratory criteria.In the light of the commentary,future research may lead us to define subtypes of lupus from a genomic and proteomic standpoint.