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目的：探讨ｃ－ｅｒｂＢ－２ 表达与乳腺癌生物学行为及预后的关系。方法：采用免疫组化技术，检测５０ 例乳腺癌ｃ－ｅｒｂＢ－２ 蛋白的表达情况。结果：２４ 例（４８．００％ ）ｃ－ｅｒｂＢ－２ 蛋白表达阳性，ｃ－ｅｒｂＢ－２蛋白表达在有淋巴结转移的乳腺癌中较多见（Ｐ＜ ０．０５），其阳性组５ 年生存率低于阴性组（Ｐ＜０．０５），ｃ－ｅｒｂＢ－２ 蛋白表达不是影响乳腺癌患者预后的独立因素。结论：ｃ－ｅｒｂＢ－２ 蛋白表达与乳腺癌的转移及预后密切相关。
Objective: To investigate the relationship between c-erbB-2 expression and biological behavior and prognosis of breast cancer. Methods: Immunohistochemistry was used to detect the expression of c-erbB-2 protein in 50 cases of breast cancer. Results: The expression of c-erbB-2 protein was positive in 24 cases (48.00%), c-erbB-2 protein expression was more common in breast cancer with lymph node metastasis (P<0.05), and the positive group was 5 years. The survival rate was lower than that of the negative group (P<0.05), and c-erbB-2 protein expression was not an independent factor that affected the prognosis of breast cancer patients. Conclusion: The expression of c-erbB-2 protein is closely related to the metastasis and prognosis of breast cancer.