人体细胞核内存在一类具有基因调控作用的核受体(nuc1ear receptor),其中包含大量因配基,靶基因及生理活性不完全清楚者而被称作孤立核受体(orphan nuclear recepe-tors,ONR)。肝X受体(liver Xreceptors,LXRs)就是一种氧化固醇激活的孤立核受体,参与机体多种生理活动的调节,包 There is a kind of nuclear receptor (nuc1ear receptor) with gene regulation in the human body nucleus, which contains a large number of ligands, target genes and physiological activity is not completely clear and called isolated nuclear receptor (orphan nuclear recepe-tors, ONR). Liver X receptors (LXRs) are isolated nuclear receptors activated by oxidized sterols and are involved in the regulation of many physiological activities of the body, including