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切除雌鼠双侧卵巢造成快速骨丢失，复制女性绝经后骨质疏松症的动物模型。以饲料添加方式补充维生素Ｋ（９０ｍｇ／ｋｇ） 和钙（５ｇ／ｋｇ） 。实验期６ 个月，通过测定尿钙、尿羟脯氨酸、血清钙、碱性磷酸酶、骨钙素等生化指标观察单纯补充维生素Ｋ、钙及两者联合作用对骨代谢的影响。结果发现：补充Ｖｋ 可减少尿钙、尿羟脯氨酸排泄，降低血清碱性磷酸酶水平，提高血清骨钙素及其羧化水平，表明维生素Ｋ 能抑制骨分解代谢，促进骨形成代谢，并且与钙的联合作用效果优于单纯补充维生素Ｋ 或钙。本实验结果提示：绝经后妇女作为骨质疏松危险人群，应注意膳食维生素Ｋ 与钙的摄入。大剂量的维生素Ｋ 有可能被用于骨质疏松症的药物防治
Animal models of female postmenopausal osteoporosis were created by resection of both ovaries causing rapid bone loss. Vitamin K (90 mg / kg) and calcium (5 g / kg) were added as feed. Six months after the experiment, the effects of vitamin K, calcium and their combined effects on bone metabolism were observed by measuring urinary calcium, urinary hydroxyproline, serum calcium, alkaline phosphatase and osteocalcin. The results showed that: Supplementing Vk can reduce urinary calcium and urinary hydroxyproline excretion, lower serum alkaline phosphatase level and increase serum osteocalcin and carboxylation levels, indicating that vitamin K can inhibit bone catabolism and promote bone formation and metabolism, And the combined effect with calcium is better than simply vitamin K or calcium supplement. The results suggest that: postmenopausal women as risk groups of osteoporosis, should pay attention to dietary intake of vitamin K and calcium. High doses of vitamin K may be used for the prevention and treatment of osteoporosis