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高血糖是重症监护病房脓毒症危重患者常见问题，脓毒症血糖水平的上升导致了发病率和病死率的增加，而且脓毒症高血糖的病理生理学特别是治疗仍存在争议。在管理脓毒症患者临床实践中，血糖的控制水平、低血糖、变异度、病死率、营养支持等方面必须被重视。积极干预脓毒症患者血糖的变化，将血糖控制在一定范围内有助于减少并发症的发生。目前脓毒症患者最佳血糖控制水平仍不明确，妥善营养支持、避免低血糖、降低变异度，有利于降低病死率。“,”Hyperglycemia is a commonly encountered issue in critically ill patients with sepsis in the intensive care unit.The elevation of sepsis glucose leads to higher morbidity and mortality ,however the patho-physiology and,in particular,the treatment of hyperglycemia remains controversial.In clinical practice,several aspects must be taken into account in the management of these patients,including blood glucose targets, hypoglycemia,glucose variability,fatality,nutritional support and so on.Active maintenance of the level of blood glucose within an acceptable range helps to reduce the incidence of complications.The optimal glyce-mic control level for patients with sepsis remains unclear.Proper nutritional support,avoiding hypoglycemia and reducing blood glucose variability are helpful to decreasing the fatality .