许多自身免疫性溶血性贫血(AIHA),因溶血轻而不必治疗,控制原发疾病常可有效控制溶贫。严重者需应用皮质类固醇,细胞毒药物,输注红细胞或脾切除术等常规治疗。但对难治性病例较困难。新近,对个别病例应用血浆置换术获得满意效果。作者报道1例难治性温抗体型AIHA,对常规治疗无效,应用血浆置换术取得完全缓解。患者女性,16岁,贫血,乏力,发热,黄疸,恶心,呕吐。无感染及服任何药物史。无淋巴结病或肝肿大,脾肋下3-4cm。血红蛋白46g/l,红细胞1.2× Many autoimmune hemolytic anemia (AIHA), due to hemolytic light without treatment, control of primary disease often can effectively control the solution to poverty. Severe cases need to apply corticosteroids, cytotoxic drugs, transfusion of red blood cells or splenectomy and other conventional treatment. But difficult cases of refractory. Recently, the application of plasma exchange in individual cases to obtain satisfactory results. The authors report that 1 case of refractory warm antibody type AIHA, routine treatment ineffective, achieved complete remission by plasmapheresis. Patient Female, 16 years old, anemic, weak, fever, jaundice, nausea, vomiting. No infection and any medication history. No lymphadenopathy or hepatomegaly, spleen ribs 3-4cm. Hemoglobin 46g / l, red blood cells 1.2 ×