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目的:探讨关节盘前移后双板区的适应性改建。方法:日本大白兔30只,先制作成关节盘前移位动物模型,定期处死,取关节标本作HE染色、阿尔辛蓝、间苯二酚-品红染色、细胞凋亡检查和蛋白多糖含量测量。结果:在关节盘移位的初期,双板区即发生细胞凋亡,胶原纤维和弹力纤维排列紊乱、断裂;蛋白多糖先是急剧下降,然后缓慢上升。4周后,双板区内可出现软骨样细胞或典型的软骨组织。结论:双板区在关节盘移位后会进行重构,使之成为类似纤维软骨样组织。
Objective: To explore the adaptive reconstruction of the double plate area after the advancement of the joint disc. Methods: Thirty rabbits in Japan were made into an anterior pancreas animal model and sacrificed on a regular basis. The joint specimens were stained with HE, Alcian blue, resorcinol-magenta staining, apoptosis and proteoglycan contents . Results: In the early stage of joint disc displacement, apoptosis occurred in the bilobal area, collagen fibers and elastic fibers arranged disorganized and ruptured; proteoglycans dropped sharply first and then slowly increased. After 4 weeks, cartilage-like cells or typical cartilage tissue may appear in the double plate area. CONCLUSIONS: The double plate area is reconstructed after disc displacement, rendering it similar to fibrocartilage-like tissue.