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目的 :探讨新生儿硬肿症并多器官功能不全综合征 (MODS)的临床特征 ,探寻有效的治疗对策 ,降低MODS的发生率和病死率。方法 :对 80年代以来入住我院的新生儿硬肿症并MODS患儿 ,分成两个阶段进行回顾对比分析研究。结果 :90年代MODS患儿 ,两个器官受损发生率比 80年代高 ,4个和 4个以上器官受损发生率比 80年代低。 90年代的病死率 ( 9 5% )明显低于 80年代 ( 57 7% ) (P <0 .0 1)。结论 :密切观察新生儿硬肿症的相对稳定期及受累脏器功能失常的特征 ,不失时机地恰当改善循环 ,合理应用抗生素 ,进行代谢营养支持和器官功能支持是降低新生儿硬肿症并MODS的发生率和病死率 ,提高治愈率的重要措施。
Objective: To explore the clinical features of neonatal scleredema and multiple organ dysfunction syndrome (MODS) and explore effective treatment strategies to reduce the incidence of MODS and mortality. Methods: Children with MODS in our hospital who had been admitted to our hospital since the 1980s were divided into two stages and compared retrospectively. Results: In the 90s, the incidence of organ damage in two MODS children was higher than that in the 1980s. The incidence of organ damage in four or more organs was lower than that in the 1980s. The case fatality rate (95%) in the 1990s was significantly lower than that in the 1980s (57.7%) (P <0.01). Conclusions: Close observation of the relative stability of neonatal sclerema and the characteristics of organ dysfunction, seizing the opportunity to properly improve circulation, rational use of antibiotics, metabolic and nutritional support and organ function support is to reduce neonatal sclerous disease and MODS Incidence and mortality, an important measure to improve the cure rate.