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目的：了解胎盘型谷胱甘肽转移酶（ＧＳＴ－π）在喉息肉、鳞状上皮乳头状瘤、鳞状细胞癌的表达状况，探讨ＧＳＴ－π与上述病变之间的关系及意义。方法：常规病理诊断选择喉息肉１０例、乳头状瘤１０例、鳞状细胞癌２０例，用免疫组化ＬＳＡＢ法检测ＧＳＴ－π，统计学处理。结果：ＧＳＴ－π表达在喉息肉及癌旁正常鳞状上皮均为阴性，不典型增生鳞状上皮ＧＳＴ－π呈阳性表达。ＧＳＴ－π阳性率在喉乳头状瘤和喉鳞状细胞癌分别为２０％和８５％，两者之间差异具有显著性。结论：ＧＳＴ－π在喉良恶性肿瘤检测、判断病变进展及转归方面具有重要意义。
Objective: To investigate the expression of GST-π in laryngeal polyp, squamous cell carcinoma of the larynx and squamous cell carcinoma, and to explore the relationship between GST-π and the above lesions. Methods: The routine pathological diagnosis of laryngopharyngeal polyps in 10 cases, 10 cases of papilloma, squamous cell carcinoma in 20 cases, immunohistochemical LSAB method for the detection of GST-π, statistical analysis. Results: The expression of GST-π was negative in laryngeal polyp and adjacent normal squamous epithelium, while the expression of GST-π in atypical hyperplasia squamous epithelium was positive. The positive rate of GST-π in laryngeal papilloma and laryngeal squamous cell carcinoma was 20% and 85% respectively, the difference was significant. Conclusion: GST-π is of great significance in detecting benign and malignant tumors and judging the progress and prognosis of the lesions.