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为探讨抗凋亡基因ｂｃｌ－２及转移抑制基因ｎｍ２３对乳腺癌生物学行为的影响，对乳腺癌４０例进行了免疫组化检测。结果表明，ｂｃｌ－２表达与患者年龄、肿瘤大小、有无淋巴结转移无关，而与乳腺癌组织学分级呈负相关，高、中分化组ｂｃｌ－２表达率高于低分化组（Ｐ＝０．００４１）。ｎｍ２３低表达与淋巴结转移有关（Ｐ＜０．０５），也与乳腺癌低分化有关（Ｐ＝０．００７６）。ｂｃｌ－２与ｎｍ２３表达呈正相关。ｂｃｌ－２影响乳腺癌的分化，而ｎｍ２３除抑制肿瘤转移外，也与分化程度有关。乳腺癌中，ｂｃｌ－２和ｎｍ２３共同表达可能代表恶性程度较低的一种类型。
In order to investigate the effect of anti-apoptosis gene bcl-2 and metastasis suppressor gene nm23 on the biological behavior of breast cancer, 40 cases of breast cancer were detected by immunohistochemistry. The results showed that bcl-2 expression was not associated with age, tumor size, and lymph node metastasis, but negatively correlated with histological grading of breast cancer. The expression of bcl-2 was significantly higher in the high and moderately differentiated group than in the poorly differentiated group (P=0. .0041). The low expression of nm23 was associated with lymph node metastasis (P<0.05) and was also associated with poor differentiation of breast cancer (P=0.0076). There was a positive correlation between bcl-2 and nm23 expression. Bcl-2 affects the differentiation of breast cancer, and nm23 is related to the degree of differentiation in addition to the inhibition of tumor metastasis. In breast cancer, the co-expression of bcl-2 and nm23 may represent a less malignant form.