目的探讨高血压性心脏病失代偿期伴焦虑、抑郁的患者常规抗心力衰竭治疗联合氟哌噻吨美利曲辛片的疗效。方法选取符合标准的伴有焦虑、抑郁症的高血压性心脏病失代偿期患者50例,随机将其分为两组。观察组患者按常规抗心力衰竭治疗加用氟哌噻吨美利曲辛片治疗,对照组患者按常规抗心心力衰竭治疗。两组患者治疗2周,观察患者焦虑、抑郁等症状的改善情况及N端脑钠肽(BNP)水平下降情况。结果观察组患者患者治疗后的焦虑自评量表(SAS)、抑郁自评量表(SDS)评分及心力衰竭疗效、N端脑钠肽(BNP)下降、彩色超声多普检测指标均明显优于对照组(均P<0.01)。结论伴有焦虑、抑郁症状的高血压性心脏病失代偿期患者常规抗心力衰竭合并应用氟哌噻吨美利曲辛片治疗,与单纯常规标准抗心力衰竭治疗相比较,能明显改善焦虑抑郁症状并提高抗心力衰竭治疗效果。 Objective To investigate the curative effect of conventional anti-heart failure treatment combined with flupentixol and melitracen tablets in patients with decompensated hypertensive heart disease accompanied by anxiety and depression. Methods Fifty patients with decompensated hypertensive heart disease accompanied by anxiety and depression were selected and randomly divided into two groups. Patients in the observation group were treated with routine anti-heart failure plus flupentixol and melitracen tablets, and patients in the control group were treated with conventional anti-heart failure. Two groups of patients were treated for 2 weeks to observe the improvement of anxiety, depression and other symptoms of patients and N-terminal brain natriuretic peptide (BNP) levels decline. Results After the treatment, the self-rating anxiety scale (SAS), the self-rating depression scale (SDS) and the curative effect of heart failure in the observation group were significantly lower than those in the control group In the control group (all P <0.01). Conclusions Patients with decompensated hypertensive heart disease accompanied by anxiety and depressive symptoms and conventional anti-heart failure combined with flupentixol and melitracen tablets can significantly improve the anxiety and anxiety abilities compared with the conventional standard anti-heart failure treatment Depression symptoms and improve anti-heart failure treatment.