五味子是常用的中药,我们在1974年开始研究五味子丙素的合成,得到一系列联苯衍生物。其中4,4′-二甲氧基-5,6,5′,6′二次甲二氧基-2,2′-二甲氧羰基联苯(简称α-联笨双酯1),有明显的药理作用。在此同时通过不同中间体溴化物合成并分离到两个异构体β-联苯双酯(2),熔点206～208℃及γ-联苯双酯(3),熔点150～152℃。 Schisandra is commonly used in traditional Chinese medicine, we started in 1974 to study the synthesis of Schisandra C, get a series of biphenyl derivatives. Among them, 4,4’-dimethoxy-5,6,5 ’, 6’ dimethoxy-2,2’-dimethoxycarbonylbiphenyl Obvious pharmacological effects. At the same time, two isomers of β-bifendate (2) were synthesized and separated from different intermediate bromides. Their melting points were 206 ~ 208 ℃ and γ-biphenyldicarboxylates (3). The melting points ranged from 150 ℃ to 152 ℃.