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乳腺癌的发生和发展受多基因的协同作用,有关P~(53)基因及nm23-H_1基因与肿瘤转移的研究已有报道,但其在乳腺癌组织中表达的变化规律、在淋巴结转移中的作用以及二者表达的相互关系报道甚少。本文采用免疫组化方法检测了56例乳腺癌患者癌组织中nm23-H_1及P~(53)的表达情况,旨在探讨其与乳腺癌预后的关系。1 临床资料1.1 一般资料 收集1993～1995年新乡医学院第一附属医院病理科乳腺组织标本共76份,全部标本均经10％中性福尔马林固定,常规石蜡切片,HE染
The occurrence and development of breast cancer are synergized by multiple genes. Although studies on P53 gene and nm23-Hl gene and tumor metastasis have been reported, the expression of P53 gene and tumor metastasis in breast cancer has been reported in lymph node metastasis The role of the two expressions and the interrelationship of very few reports. In this study, immunohistochemistry was used to detect the expression of nm23-H 1 and P 53 in 56 cases of breast cancer, and to investigate the relationship between the expression of nm23-H 1 and the prognosis of breast cancer. 1 Clinical data 1.1 General Information Collection 1993-1995 First Affiliated Hospital of Xinxiang Medical University, Department of Pathology, a total of 76 breast tissue specimens, all specimens were fixed by 10% neutral formalin, conventional paraffin sections, HE staining