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糖尿病微血管病变是糖尿病患者致死、致残的重要并发症,其发病机理仍未明了。作者针对这方面进行了系列的研究。本研究分3个部分:①糖尿病病人的纤维蛋白原、纤维蛋白(原)降解产物、第Ⅵ因子相关抗原的临床研究;②糖尿病患者血小板聚集、血栓素B生成与。cAMP含量关系;③NIDDM病人血小板聚集、第Ⅵ因子相关抗原的临床研究。分别从糖尿病病人的内皮损伤、血小板功能的改变及其可能的发病机制和磺脲类药物对它们的作用等进行了系统和深入的探讨。结果揭示糖尿病患者存在着磷脂酶活性异常,使TXA2升高,
Diabetic microangiopathy is an important complication of death and disability in patients with diabetes, and its pathogenesis remains unclear. The author conducted a series of studies on this aspect. This study is divided into three parts: ① diabetic patients fibrinogen, fibrin (prot) degradation products, factor Ⅵ factor-related clinical research; ② platelet aggregation in patients with diabetes, thromboxane B production and. cAMP content; ③ NIDDM patients with platelet aggregation, factor Ⅵ related antigen clinical research. From the diabetic patients with endothelial damage, changes in platelet function and its possible pathogenesis and the role of sulfonylureas their role in a systematic and in-depth discussion. The results revealed that diabetes patients with abnormal phospholipase activity, TXA2 increased,