高级糖基化终产物(AGEs)的形成一般是伴随糖尿病(可能还有炎症)的一种重要的生化异常。晚近的诸多研究提示,糖尿病人的动脉粥样硬化进展迅速可能与AGEs影响血管壁的自稳态有关。由于高血糖和氧化应激,糖尿病人的AGEs生成加速。血管壁内,与胶原-相边界的AGEs摄取多种血浆蛋白,消 The formation of advanced glycation end products (AGEs) is generally an important biochemical abnormality associated with diabetes (and possibly inflammation). Recent studies have shown that atherosclerosis in diabetic patients with rapid progress may be related to AGEs affect the autophagy of the vessel wall. Due to hyperglycemia and oxidative stress, AGEs production in diabetic patients is accelerated. AGEs in the vessel wall and collagen-phase boundary uptake a variety of plasma proteins, eliminating