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目的:探讨慢性阻塞性肺病(COPD)患者血清酶变化规律及其临床意义。方法:对100例COPD急性加重期患者,同时测定血清酶LDH、AST、CPK、CPK-MB、及PaO_2,并与正常对照组及稳定期组对比。结果:COPD急性发作期血清酶明显高于正常组(P<0.01),且除CPK外,明显高于稳定期(P<0.05);PaO_2与血清酶除CPK外,AST、CPK-MB、LDH间均存在低—中度直线负相关关系。结论:动态监测血清酶既可作为COPD急性发作期的辅助诊断指标,还可以作为反映患者缺氧严重程度及预后的有力指标。
Objective: To investigate the changes of serum enzymes in patients with chronic obstructive pulmonary disease (COPD) and its clinical significance. Methods: Serum enzymes LDH, AST, CPK, CPK-MB, and PaO_2 were measured in 100 patients with exacerbation of COPD and compared with normal control group and stable group. Results: The levels of serum enzymes in acute exacerbation of COPD were significantly higher than those in normal group (P <0.01), and were significantly higher than those in control group except CPK (P <0.05) There is a low-moderate linear negative correlation between. Conclusion: Dynamic monitoring of serum enzymes can be used as an auxiliary diagnosis of COPD during acute exacerbation, but also can be used as a strong indicator of the severity and prognosis of patients with hypoxia.