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本实验采用马桑内酯肌注造成化学点燃效应癫痫动物模型，并于点燃后连续用药４０次，模拟人类长期反复全身强直－阵挛发作，然后进行海马区脑组织的光镜、电镜和免疫组化观察分析。结果表明，长期反复抽搐动物的海马区星形胶质细胞发生明显的变性坏死。提示马桑内酯对星形胶质细胞有损伤性作用，这种损伤可能在诱导痫性发作中起一定作用
In this study, intramuscular injection of docetaxel led to the chemical ignition effect of epilepsy animal model, and after ignite 40 times in a row to simulate human long-term repeated tonic-clonic seizures, and then light microscopy, electron microscopy and immunization of hippocampus brain tissue Histopathological analysis. The results show that long-term repeated convulsions of hippocampal astrocytes significantly degeneration and necrosis. Suggesting that there is a damaging effect of the docetaxel on astrocytes, and this damage may play a role in inducing seizures