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血管重构性疾病形成和发展的根本原因之一是血管平滑肌细胞(vascular smooth muscle cells,VSMC)发生表型转化(由收缩型转变为合成型),丧失收缩功能而获得增殖、迁移的能力。在此过程中,VSMC上多种钙离子相关通道:如L-型钙离子通道(L-Ca通道)、瞬时受体电位通道(TRPC)、三磷酸肌醇受体(IP3R)通道及钙激活的钾(KCa)通道等发生功能、数量和通道结构上的改变。本文关注的是不同离子通道的相应变化,以期对该类型疾病的发病机制及可能的药物治疗提供理论的依据。
One of the fundamental reasons for the formation and development of vascular remodeling disease is the phenotypic transformation of vascular smooth muscle cells (VSMCs) from the contractile to the synthetic and the ability to gain proliferation and migration after losing the contractile function. In this process, a variety of calcium-related channels on VSMCs such as L-type calcium channel (L-Ca channel), transient receptor potential channel (TRPC), inositol 1,4,5triphosphate receptor (IP3R) channel and calcium activation Potassium (KCa) channels and other functions, the number and structure of the channel changes. This article focuses on the corresponding changes in different ion channels in order to provide a theoretical basis for the pathogenesis of this type of disease and possible drug treatment.