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作者报告2例继发于结核的肾上腺功能不全患者,其急性肾上腺危象显然是由利福平诱发。例1 男性,65岁。有咳嗽及体重减轻,体检可见全身皮肤色素沉着。胸部X线片显示左肺上叶有微小浸润病灶,痰培养4周后有少量耐酸杆菌生长。血清钠浓度为135mEg/L,钾浓度为5.14mEq/L,尿素浓度为33.7mg/dl,血压为140/90mmHg。治疗开始每日给予利福平600mg,异烟肼300mg及乙胺丁醇1g。入院前患者出现头晕和嗜睡,并有脱水,血压
The authors report 2 patients with adrenal insufficiency secondary to tuberculosis whose acute adrenal crisis is apparently induced by rifampicin. Example 1 male, 65 years old. Cough and weight loss, physical examination showed systemic skin pigmentation. Chest X-ray showed a slight infiltration of lesions in the left upper lobe, a small amount of acid-fast bacilli growth after 4 weeks of sputum culture. The serum sodium concentration was 135 mEg / L, the potassium concentration was 5.14 mEq / L, the urea concentration was 33.7 mg / dl, and the blood pressure was 140/90 mmHg. Treatment began daily rifampicin 600mg, isoniazid 300mg and ethambutol 1g. Patients before admission dizziness and drowsiness, and dehydration, blood pressure