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目的探讨轻度慢性乙型病毒性肝炎(CHB)患者E抗原(HBe Ag)、血清白蛋白(ALB)、球蛋白(GLB)与肝组织病理学的关系。方法选取275例轻度CHB患者的肝穿病理报告,比较HBe Ag阳性和阴性患者肝组织病理的分级、分期,并分析肝组织炎症分级及纤维化程度与血清ALB,GLB之间的相关性。结果HBe Ag阳性组与阴性组的病理炎症分级及纤维化程度差异均无统计意义(P>0.05);血清ALB在不同肝脏炎症分级和纤维化分期间均有统计意义(r=-0.283,r=-0.134,P<0.05);血清GLB在不同肝脏炎症分级间有统计意义(r=0.292,P<0.05),不同纤维化分期无统计意义(r=0.057,P>0.05)。结论 HBe Ag阴性的轻度患者炎症和纤维化改变与HBe Ag阳性患者无明显差异,临床上血清ALB和GLB在一定程度上可作为反映CHB患者肝脏病理损伤程度的指标。
Objective To investigate the relationship between HBeAg, serum albumin (ALB), globin (GLB) and liver histopathology in patients with mild chronic hepatitis B (CHB). Methods Pathological reports of liver biopsy in 275 mild CHB patients were collected. The pathological grading and staging of liver tissue in HBe Ag positive and negative patients were compared. The correlation between the grade of inflammation, the degree of fibrosis and the serum ALB and GLB was also analyzed. Results There was no significant difference in pathological grade and degree of fibrosis between HBe Ag positive group and negative group (P> 0.05). Serum ALB was statistically different between different grades of liver inflammation and fibrosis stage (r = -0.283, r = -0.134, P <0.05). Serum GLB had statistical significance between different grades of liver inflammation (r = 0.292, P <0.05). There was no significant difference in different stages of fibrosis (r = 0.057, P> 0.05). Conclusions There is no significant difference between inflammation and fibrosis in HBe Ag-negative patients and HBeAg-positive patients. Serum ALB and GLB may be used as indexes to reflect the extent of liver pathological injury in CHB patients.