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目的评价IL-6 174G/C和-572G/C基因多态性与胃癌风险的相关关系以及IL-6基因多态性与幽门螺杆菌感染和吸烟的交互作用。方法采用病例对照研究方法,纳入某院2008年1月到2011年5月新发胃癌191例,191例非肿瘤病人作为对照。采用PCR-RFLP方法测定IL-6 174G/C和-572G/C的基因分型。结果研究发现携带IL-6 174CC基因型和C等位基因型胃癌发病风险显著增高,调整后的OR值(95%CI)分别为1.69(0.97~2.98)和1.75(1.16~3.25)。而未发现IL-6 572G/C基因多态性与胃癌发病率的相关关系。结论本研究结果表明IL-6基因多态性可能具有促进胃癌发生和发展的作用,IL-6可以作为胃癌遗传学的检测指标,用于检验胃癌易感个体的生物学指标。
Objective To evaluate the association between IL-6 174G / C and -572G / C polymorphisms and the risk of gastric cancer and the interaction between IL-6 gene polymorphism and Helicobacter pylori infection and smoking. Methods A case-control study was conducted in 191 newly diagnosed cases of gastric cancer and 191 non-tumor patients from January 2008 to May 2011 in a hospital. The genotypes of IL-6 174G / C and -572G / C were determined by the PCR-RFLP method. Results The risk of developing gastric cancer with IL-6 174CC genotype and C allele was significantly increased. The adjusted odds ratio (95% CI) was 1.69 (0.97-2.98) and 1.75 (1.16-3.25), respectively. No correlation was found between IL-6 572G / C polymorphism and the incidence of gastric cancer. Conclusion The results of this study indicate that IL-6 gene polymorphism may promote the occurrence and development of gastric cancer. IL-6 may be used as a genetic marker of gastric cancer to test the biological indicators of gastric cancer susceptible individuals.