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尼莫地平(nimodipine,NMD)是作用于脑血管平滑肌的钙通道阻滞剂,可扩张脑动脉和增加脑血流量。临床主要用于治疗脑血管疾病、突发性耳聋及痴呆症等,常见的不良反应有胃肠道不适、口干、头晕、皮肤发红、发痒。近年NMD不良反应的报道日趋增多: 1 顽固性呃逆 男,52岁。诊断:高血压病,脑血栓形成后遗症。口服NMD40mg,3次/日。第3天出现顽固性呃逆,重时10～12次/分。经肌肉注射甲氧氯普胺、阿托品穴位(内关、足三里)注射及针灸等治疗仅暂时好转。次日停服NMD,第6天呃逆停止。第7天血压升至24/13.3kPa,又服NMD,剂量同前,第4天再次出现呃逆,持续10余小时不消失。停用该药,改服卡托普利,2天后呃逆完全消失,后做上消
Nimodipine (NMD) is a calcium channel blocker that acts on cerebrovascular smooth muscle to expand cerebral arteries and increase cerebral blood flow. Clinical mainly for the treatment of cerebrovascular disease, sudden deafness and dementia, common adverse reactions are gastrointestinal discomfort, dry mouth, dizziness, redness of the skin, itching. In recent years, increasing reports of adverse reactions to NMD: 1 stubborn hiccups male, 52 years old. Diagnosis: Hypertension, cerebral thrombosis sequelae. Oral NMD 40mg, 3 times / day. On the third day of intractable hiccups, heavy 10 to 12 beats / min. After intramuscular metoclopramide, atropine acupuncture points (Neiguan, Zusanli) injection and acupuncture and other treatments only temporarily improved. The next day to stop taking NMD, the first 6 days hiccups stop. Day 7 blood pressure rose to 24 / 13.3kPa, and served NMD, the same dose as before, again on the fourth day, hiccups, sustained 10 hours does not disappear. Stop using the drug, change service captopril, hiccup disappeared completely after 2 days, do top off