1921年Loewi在刺激动物的迷走神经时,发现从神经周围的灌流液小,出现一种能抑制其他动物心脏的物质,当时称之为迷走物质,五年后证明它就是乙酰胆硷。此后,在半个世纪中,已经阐明它是一种外周神经(如:运动神经、交感及付交感神经的节前纤维和付交感神经的节后纤维等等)的神经介质;近年来又重视了它做为一种中枢神经 In 1921 when Loewi stimulated the animal’s vagus nerve, it was found that the perfused fluid around the nerve was small and a substance that inhibited the heart of other animals was found. At that time, Loewi proved to be a vagusized substance and proved acetylcholine after five years. Since then, in half a century, it has been clarified that it is a nerve mediator of peripheral nerves (eg, motor nerves, sympathetic and sympathetic preganglionic fibers and sympathetic postganglionic fibers, etc.) and in recent years It is used as a central nervous system