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目的探讨莫沙必利联合匹维溴铵治疗肠易激综合征(irritable bowel syndromes,IBS)的疗效。方法选取86例病例随机分为两组,对照组与治疗组各43例。对照组采用匹维溴铵口服治疗,治疗组采用莫沙必利联合匹维溴铵口服治疗,两组的治疗时间与评价标准相同,治疗结束后,评价两组的治疗效果与复发率。结果对照组的总有效率为55.81%,治疗组的总有效率为81.40%,两组对比差异有显著性(P<0.025),对照组的复发率为53.49%,治疗组的复发率为27.91%,两组对比差异有显著性,(P<0.05)。结论莫沙必利联合匹维溴铵治疗IBS总有效率高、复发率低,是一种有效的治疗方案,值得临床推广。
Objective To investigate the efficacy of mosapride and pinaverium bromide in the treatment of irritable bowel syndrome (IBS). Methods 86 cases were randomly divided into two groups, the control group and the treatment group of 43 cases. The control group was treated with pinaverium bromide orally. The treatment group was treated with mosapride and pinaverium bromide orally. The treatment time and evaluation criteria were the same in both groups. After treatment, the therapeutic effect and recurrence rate were evaluated. Results The total effective rate of the control group was 55.81%, the total effective rate of the treatment group was 81.40%, there was significant difference between the two groups (P <0.025), the recurrence rate of the control group was 53.49%, the recurrence rate of the treatment group was 27.91 %, The difference between the two groups was significant (P <0.05). Conclusion The combination of mosapride and pinaverium bromide is an effective treatment for IBS with high total effective rate and low recurrence rate, which is worthy of clinical promotion.