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葛花及其代表方剂“葛花解醒汤”历来被用于酒中毒、食欲不振、呕吐等。本文对其各提取部位进行药理研究。将葛花按下述分离提取方法分别获得甲醇提取物(PE-ME)、异黄酮类部位(PF-IF)、三萜皂甙部位(PF-SP)和N-酰基-N_1-葡萄糖基-色氨酸(PE-P)。它们对醇诱导的小鼠代谢异常(血中葡萄糖BG、甘油三酸酯TG和尿氮BUN浓度)和对实验肝损害(CCl_4模型和高脂肪喂饲诱导的模型)的研究表明。 PF-ME(4500mg/kg)和PF-P(400mg/kg)能抑制醇诱导的小鼠BG的升高,而PF-IF(1000mg/kg)和PF-SP(1000mg/kg)无效。PF-
Gehua and its representative formula “Gehua Jiexue Decoction” have been used for wine poisoning, loss of appetite, and vomiting. In this article, pharmacological studies were carried out on the extracted parts. Pueraria was extracted by the following extraction method to obtain methanol extract (PE-ME), isoflavone (PF-IF), triterpene saponin (PF-SP) and N-acyl-N-1-glucosyl-color (PE-P). They show that alcohol-induced abnormalities in mouse metabolism (glucose BG, triglyceride TG, and urine nitrogen BUN concentrations in the blood) and experimental liver damage (models induced by the CCl_4 model and high-fat feeding) are shown. PF-ME (4500 mg/kg) and PF-P (400 mg/kg) inhibit alcohol-induced increases in mouse BG, whereas PF-IF (1000 mg/kg) and PF-SP (1000 mg/kg) are ineffective. PF-