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[目的]探讨微生态制剂在根除幽门螺杆菌治疗中的价值。[方法]选取初次就诊仅十二指肠球部活动期溃疡且幽门螺杆菌阳性,并能积极配合完成治疗的患者84例,将其随机分为A组、B组、C组。A组:常规四联疗法(泮托拉唑+胶体果胶铋+阿莫西林+呋喃唑酮),B组:常规四联疗法+双歧三联活菌胶囊,C组:常规四联疗法+乳酸菌素片;3组疗程均为6个月。于治疗后2周、4周,分别检测各组患者的溃疡愈合情况和小肠细菌生长情况,于治疗6个月时检查幽门螺杆菌根除情况,并进行组间两两比较。[结果]1溃疡愈合情况:治疗2周时,愈合总有效率:C组(96.43%)>B组(85.71%)>A组(78.57%),治疗4周时,愈合总有效率:C组(100%)>B组(89.29%)>A组(82.14%),C组与B组、A组比较差异有统计学意义(P<0.05),但B组与A组比较差异无统计学意义(P>0.05)。2小肠细菌生长情况:治疗2周时,3组两两间比较差异有统计学意义(P<0.01);治疗4周时,A组与B组、C组比较差异均有统计学意义(P<0.05),但B组与C组比较差异无统计学意义(P>0.05)。3幽门螺杆菌根除情况:治疗6个月时,幽门螺杆菌根除率C组(92.86%)>B组(82.14%)>A组(57.14%),组间比较差异有统计学意义(P<0.01)。[结论]在根除幽门螺杆菌治疗中,应用微生态制剂能快速、稳定地促进溃疡愈合,并能有效降低肠道菌群失调,显著提高幽门螺杆菌的根除率,应用死菌制剂(乳酸菌素片)效果更明显,值得临床推广。
[Objective] To investigate the value of probiotics in the treatment of Helicobacter pylori eradication. [Methods] Eighty - four patients with active ulceration of the duodenal bulb and active Helicobacter pylori who were active in the treatment of primary duodenal bulb were selected and randomly divided into A, B and C groups. Group A: Conventional quadruple therapy (pantoprazole + colloidal bismuth pectin + amoxicillin + furazolidone), group B: conventional quadruple therapy + bifidobacterium triple viable capsule, group C: conventional quadruple therapy plus lactacid Tablets; 3 groups of treatment are 6 months. At 2 weeks and 4 weeks after treatment, ulcer healing and intestinal bacterial growth were examined in each group. Helicobacter pylori eradication was examined at 6 months of treatment, and any two groups were compared. [Result] The healing of ulcer: The total effective rate of healing in two weeks was 96.43% in group C, 85.71% in group B, 78.57% in group A, and the total effective rate was C (100%)> B (89.29%)> A (82.14%). There was significant difference between group C and group B and group A (P <0.05), but there was no statistical difference between group B and group A Significance (P> 0.05). The growth of small intestine bacteria: After 2 weeks of treatment, the difference between the two groups was statistically significant (P <0.01); at the 4th week, there was significant difference between group A and group B and group C (P <0.05), but there was no significant difference between group B and group C (P> 0.05). 3 Helicobacter pylori eradication: Helicobacter pylori eradication rate in group C (92.86%)> B (82.14%)> A (57.14%) at 6 months of treatment showed statistically significant difference (P < 0.01). [Conclusion] In the eradication of Helicobacter pylori, the application of probiotics can promote the healing of ulcer quickly and steadily, and can effectively reduce the imbalance of intestinal flora, significantly improve the eradication rate of Helicobacter pylori and use the dead bacteria preparation Film) effect is more obvious, it is worth clinical promotion.