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目的 探讨胎儿颈部软组织厚度和母体血清标记物在筛查胎儿发育异常的价值.方法 收集399例孕11～14用超声测定胎儿颈部软组织(nuchal translucency,NT)厚度和1 125例孕14～21周测定母体二联血清标记物(AFP+Free-β-HCG),并对其胎儿结局进行追踪.结果 胎儿NT测定和母体血清标记物用于筛查胎儿发育异常的敏感度分别为50.00%和51.11%,特异度分别为98.69%和74.44%.胎儿NT筛查胎儿发育异常的截断值初步计算为2.25mm. 结论胎儿NT和母体血清标记(AFP+Free-β-HCG)筛查胎儿发育异常具有较高的敏感性.“,”Objective To explore the value of fetal nuchul translucency (N-T) thickness and maternal serum markers in screening fetal dysplasia. Methods There 399 NT thickness data and 1 125 second trimester maternal AFP+Free-β-HCG were collected and analyzed. Results The sensitivities of fetal NT thickness and maternal serum marker in screening fetal dysplasia were 50.00% and 51.11% ,separately,while the specificities were 98.69% and 74.44%. The cut-off value of fetal NT thickness in screening fetal dysplasia was 2.25mm. Conclusion Fetal NT thickness and maternal serum makers could be used in predicting feud dysplasia.