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本文概述了对疟疾红细胞期的获得性特异性免疫力的体液和细胞介导机理,并评价裂殖子疫苗的目前状况。疟疾的体液抗体多丙种球蛋白血症是疟疾感染的常见特征,并与 IgG 产量的增加和 IgM 水平的升高及各种自身抗体有关。生成的 Ig 中仅有一小部分与疟疾抗原结合。认为这种非特异 Ig 量的增加是灭活抑制T 细胞或刺激淋巴细胞致有丝分裂因子的发生。
This article outlines the humoral and cell-mediated mechanisms of acquired specific immunity to the malaria erythrocytic stage and assesses the current status of merozoite vaccines. Malaria humoral antibody Polygammaglobulinemia is a common feature of malaria infections and is associated with increased IgG production and elevated IgM levels and various autoantibodies. Only a small fraction of the Ig produced is bound to the malaria antigen. This increase in non-specific Ig is thought to inactivate the inhibition of T cells or stimulate lymphocyte-induced mitogenesis.