用伊文思蓝定量测定和TTC染色法,观察小檗胺对大鼠脑皮层梗塞的保护作用。结果表明:结扎大脑中动脉和同侧颈总动脉,再同时夹闭对侧颈总动脉1h,可引起大鼠脑皮层大脑中动脉分布区较大面积梗塞。小檗胺可使梗塞区伊文思蓝蓝染程度变浅,TTC染色梗塞范围缩小。说明该药对脑梗塞可能有保护作用。 Using Evans blue quantitative assay and TTC staining, the protective effect of Berbamine on cerebral cortex infarct was observed. The results showed that the ligation of the middle cerebral artery and the common carotid artery, and the simultaneous occlusion of the contralateral common carotid artery for 1 h, could cause a large area of ​​infarction in the middle cerebral artery of the rat’s cerebral cortex. Berbamine can make the Evans blue in the infarcted area lighter, and the TTC staining infarct size is reduced. This medicine may have a protective effect on cerebral infarction.