目的探讨前列地尔联合银杏达莫治疗糖尿病肾病的临床疗效。方法选取2012年10月—2013年10月安阳市安阳地区医院收治的糖尿病肾病患者66例,随机分为观察组与对照组,各33例。观察组患者给予前列地尔联合银杏达莫治疗,对照组患者给予银杏达莫治疗。观察两组患者治疗后脂联素水平、24h尿蛋白排泄率、尿蛋白及不良反应发生情况。结果观察组患者脂联素水平高于对照组,24h尿蛋白排泄率、尿蛋白低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论前列地尔联合银杏达莫治疗糖尿病肾病的临床疗效显著,能有效提高脂联素水平,降低24h尿蛋白排泄率及尿蛋白水平。 Objective To investigate the clinical efficacy of alprostadil combined with ginkgo biloba in the treatment of diabetic nephropathy. Methods Sixty-six patients with diabetic nephropathy admitted to Anyang District Anyang from October 2012 to October 2013 were randomly divided into observation group and control group, with 33 cases in each group. Patients in the observation group were treated with alprostadil combined with ginkgo biloba, while those in the control group were treated with biloba damo. The levels of adiponectin, urinary protein excretion rate, urinary protein and adverse reactions were observed in two groups after treatment. Results The level of adiponectin in the observation group was higher than that in the control group, and the urinary protein excretion rate and urinary protein in the observation group were lower than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Alprostadil combined with ginkgo biloba treatment of diabetic nephropathy significant clinical effect, can effectively increase the level of adiponectin, reduce 24h urinary protein excretion and urinary protein levels.