患女,30岁。口服异烟肼150片(15g),1h后感恶心,呕吐浅黄色胃内容物,继之出现昏迷,四肢间断性抽搐,约30min至1h抽搐发作1次,每次持续1min左右。入院查体:T36.5℃,P90次/min,R18次/min,BP18/12kPa。深昏迷,间断性全身强直性抽搐,颜面紫绀,牙关紧闭,口吐白沫,瞳孔等大等圆,直径3mm,光反应迟钝,四肢肌张力高,双下肢巴氏征(+)。入院诊断:急性异烟肼中毒。给予吸氧、输液、利尿、镇静等治疗,12h内静点维生素B_6500mg,病情无缓解,抽搐渐加重。后一次性静脉推注维生素B_65g,深昏迷渐转为浅昏迷,抽搐亦渐减轻,全身性抽搐转为四肢较轻的抽搐,约1h发作1次。第2天呈嗜睡状,双下肢偶有抽搐,肌张力仍高,双下肢肌力Ⅰ级。查肝功:GOT245U/L、GPT39U/L、AKP204U/L。继之静脉点滴维生素B615g/d。第3天,患者神志渐清,无抽搐,肌张 Women, 30 years old. Oral isoniazid 150 tablets (15g), 1h after nausea, vomiting light yellow stomach contents, followed by coma, intermittent convulsions, about 30min to 1h convulsions attack 1 time, each lasting about 1min. Admission examination: T36.5 ℃, P90 times / min, R18 times / min, BP18 / 12kPa. Deep coma, intermittent tetanic convulsions, facial cyanosis, teeth closed, foaming at the mouth, pupils and other large round, diameter 3mm, light reaction slow, high limb muscle tension, both lower extremity Pakistan’s sign (+). Admission diagnosis: acute isoniazid poisoning. Given oxygen, infusion, diuretic, sedation and other treatment, within 12h vitamins B_6500mg, no remission, twitching gradually increased. After a single intravenous injection of vitamin B_65g, deep coma gradually turned into shallow coma, convulsions also gradually reduced, generalized convulsions to limbs lighter convulsions, about 1h attack 1 times. Drowsiness on the 2nd day, occasional double lower extremity convulsions, muscle tension is still high, lower limb muscle strength Ⅰ level. Check liver function: GOT245U / L, GPT39U / L, AKP204U / L. Followed by intravenous vitamin B615g / d. On the third day, the patient gradually became conscious, without convulsion and muscle tension