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本文分别用抗人E受体、抗T_H、Ts细胞单抗的Ea花结抑制试验检测孕血清中EPF活性并对其进行了动态观察,同时检测了EPF活性与HCG-β、AFP、孕酮的关系以及对T淋巴细胞亚群的影响。结果说明:孕血清中EPF活性明显高于对照组(P<0.001)。孕血清中EPF活性主要通过对T_H细胞的作用实现。在孕早期EPF活性较高,随孕期延长活性逐渐下降,至孕6个月活性渐趋消失,分娩前10周基本消失。EPF活性与血中HCG-β、AFP浓度无关,与孕酮呈负相关。EPF不能直接抑制淋巴细胞的花结形成,但能显著地增强ATS、anti-CCT_3、anti-CD_4的花结抑制效应。
In this paper, the anti-human E receptor, anti-T_H, Ts monoclonal antibody Ea rosette inhibition assay of serum progesterone EPF activity was observed and dynamic observation of EPF activity and HCG-β, AFP, progesterone Of the relationship and the impact on T lymphocyte subsets. The results showed that EPF activity in serum was significantly higher than that in control group (P <0.001). EPF activity in serum is mainly achieved through the action of T_H cells. In the first trimester of EPF activity is higher, with prolonged activity decreased gradually during pregnancy, 6 months pregnant activity gradually disappear, basically disappeared 10 weeks before delivery. EPF activity and blood HCG-β, AFP concentration has nothing to do with progesterone was negatively correlated. EPF can not directly inhibit the formation of lymph nodes, but can significantly enhance the antitumor effect of ATS, anti-CCT_3 and anti-CD_4.