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目的探讨影响T2DM患者下肢动脉病变(PAD)的相关因素。方法采用多普勒超声测定520例T2DM患者上臂和踝部的SBP,计算踝肱指数(ABI),根据ABI,将研究对象分为PAD组(ABI≤0.9)和非PAD组(ABI>0.9),比较两组年龄、性别、吸烟指数、血脂、HbA_1c和病程等指标,并分析T2DM患者PAD的危险因素。结果 520例T2DM患者中,合并PAD者105例,发生率为20.2%。与非PAD组比较,PAD组年龄、吸烟指数、病程、高血压患病率、SBP、DBP、血清LDL-C、LDL-C/HDL-C、TC/HDL-C均升高(P<0.01)。Logistic回归分析显示,T2DM患者PAD的独立危险因素为年龄和吸烟指数(OR=1.077、1.021)。结论增龄和吸烟指数是T2DM患者发生PAD的独立危险因素。病程长、高血压和脂代谢异常与PAD发生有关。
Objective To investigate the related factors of lower extremity arterial disease (PAD) in patients with T2DM. Methods The SBP of upper arm and ankle in 520 patients with T2DM were measured by Doppler ultrasound and the ankle brachial index (ABI) was calculated. According to ABI, the subjects were divided into PAD group (ABI≤0.9) and non-PAD group (ABI> 0.9) The age, gender, smoking index, blood lipid, HbA 1c and course of disease were compared between the two groups. The risk factors of PAD in T2DM patients were also analyzed. Results Of 520 patients with T2DM, 105 were complicated with PAD, the incidence was 20.2%. Compared with non-PAD group, age, smoking index, duration of disease, the prevalence of hypertension, SBP, DBP, serum LDL-C, LDL-C / HDL-C and TC / HDL- ). Logistic regression analysis showed that the independent risk factors for PAD in T2DM patients were age and smoking index (OR = 1.077,1.021). Conclusion Aging and smoking index are independent risk factors of PAD in T2DM patients. Long course of disease, hypertension and lipid metabolism associated with PAD.