以前的研究表明,热应激导致大鼠一些组织中的β-受体明显下调,同时磷脂酶A_2(PLA_2)活性明显升高。本研究在热应激前予大鼠腹腔注射磷脂酶A_2的非特异性抑制剂QNC,以了解PLA_2激活对磷脂代谢如花生四烯酸和膜磷脂成分(磷脂酰胆碱和磷脂酰丝氨酸)的影响及其与β受体变化的关系。为进一步认识热损伤发生发展的受体学机理和寻找防治措施提供依据。研究使用雄性健康Wistar大鼠。分为三组:对照组,热应激组(大鼠在 Previous studies have shown that heat stress leads to a marked downregulation of beta-receptors in some tissues of rats, while phospholipase A2 (PLA2) activity is significantly increased. In order to understand the effect of PLA2 activation on the metabolism of phospholipids such as arachidonic acid and membrane phospholipids (phosphatidylcholine and phosphatidylserine), rats were intraperitoneally injected with QNC, a nonspecific inhibitor of phospholipase A2, before heat stress And its relationship with the changes of β receptors. It provides the basis for further understanding of the receptor mechanism of heat injury and finding control measures. Study using male healthy Wistar rats. Divided into three groups: control group, heat stress group (rat in