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目的分析p53蛋白在甲状腺乳头状癌中的表达及临床意义。方法选取66例甲状腺乳头状癌患者,同时收集12例正常甲状腺组织进行病理检测,观察p53蛋白在该类疾病中的表法情况。结果所选甲状腺乳头状癌标本中显示p53蛋白表达为阳性18例(27.27%),另外12例正常的甲状腺组织中的p53蛋白表达均显示为阴性;p53蛋白阳性表达中显示为Ⅲ级甲状腺乳头状癌所占的百分比为60.00%(6/10);Ⅰ~Ⅱ级为21.43%(12/56),比较差异有统计学意义(P<0.05)。结论 P53蛋白阳性表达与疾病的病理分级情况相关,其过度表达可能与甲状腺乳头状癌的预后具有一定的相关性,提示在今后的为临床研究中应加大研究深度,为疾病的诊断与治疗提供更有价值的建设性意见。
Objective To analyze the expression of p53 protein in papillary thyroid carcinoma and its clinical significance. Methods Sixty-six patients with thyroid papillary carcinoma were selected. Twelve normal thyroid tissues were collected for histopathological examination. The expression of p53 protein in these diseases was observed. Results The positive expression rate of p53 protein in papillary thyroid carcinoma was 18 cases (27.27%), and the expression of p53 protein in 12 cases of normal thyroid tissue was negative. The positive expression of p53 protein in papillary thyroid carcinoma showed grade Ⅲ thyroid papillary The percentage of carcinoma was 60.00% (6/10). The grade Ⅰ ~ Ⅱ was 21.43% (12/56), the difference was statistically significant (P <0.05). Conclusion The positive expression of P53 protein is related to the pathological grade of the disease. The overexpression of P53 protein may have some correlation with the prognosis of papillary thyroid carcinoma, suggesting that the depth of the study should be increased in the future for the clinical study, which should be used for the diagnosis and treatment of the disease Provide more valuable and constructive comments.