论文部分内容阅读
目的 :探讨己酮可可碱 (PTX)对内毒素 (L PS)诱导的急性肺损伤肺微血管通透性的影响。方法 :建立大鼠急性肺损伤模型 ,随机分为 L PS组、L PS+PTX组、对照组 ,检测 3组的动脉血气并行支气管肺泡灌洗液计数白细胞和白蛋白 ,肺微血管通透性指数及肺组织学检查。结果 :与对照组比较 ,L PS组及 L PS+PTX组的动脉氧分压均显著下降 ,白细胞计数增加 ,白蛋白含量及肺微血管通透性指数升高 ,肺组织学检查显示明显的炎症改变 ;与 L PS组比较 ,L PS+PTX组动脉氧分压有所改善 ,白细胞计数减少 ,白蛋白含量及肺微血管通透性指数降低 ,肺组织学检查明显好转。结论 :PTX可降低肺微血管通透性 ,对 L PS诱导的急性肺损伤有保护作用
Objective: To investigate the effect of pentoxifylline (PTX) on pulmonary microvascular permeability induced by endotoxin (LPS) in acute lung injury. Methods: Acute lung injury model in rats was established and randomly divided into L PS group, L PS + PTX group and control group. The levels of leukocyte and albumin in arterial blood gas and bronchoalveolar lavage fluid were measured in three groups. The pulmonary microvascular permeability index And lung histology. Results: Compared with the control group, the arterial oxygen pressure decreased significantly in LPS group and LPS + PTX group, the white blood cell count increased, albumin content and pulmonary microvascular permeability index increased, lung histology showed obvious inflammation Compared with LPS group, the partial pressure of oxygen in arterial blood in LPS + PTX group was improved, the white blood cell count was decreased, albumin content and pulmonary microvascular permeability index were decreased, lung histology examination improved significantly. Conclusion: PTX can reduce pulmonary microvascular permeability and protect LPS-induced acute lung injury