在各种致病因子(病毒感染、酒精中毒、胆汁郁积、循环障碍、免疫紊乱、代谢障碍和寄生虫感染等)作用下,受损的肝细胞、库普弗细胞和内皮细胞等释放大量的炎性因子,激活肝星状细胞,使其向肌成纤维细胞转化和增殖,合成和分泌大量细胞外基质,并沉积于肝脏,最终导致肝纤维化(hepatic fibrosis,HF)的形成。HF继续进展导致肝小叶结构和血液循环改建,炎症迁延不愈,进而发生弥漫 In a variety of pathogenic factors (viral infection, alcoholism, cholestasis, circulatory disorders, immune disorders, metabolic disorders and parasitic infections, etc.), damaged liver cells, Kupffer cells and endothelial cells release a large number of Inflammatory factors, which activate hepatic stellate cells, transform and proliferate into myofibroblasts, synthesize and secrete a large amount of extracellular matrix, and deposit on the liver, eventually leading to the formation of hepatic fibrosis (HF). HF continue to progress led to the structure of the hepatic lobule and blood circulation rebuild inflammation prolonged unhealed, and then diffuse