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目的探讨子综合征出血热患者血浆内毒素水平及其在病损中的作用。方法应用堂试剂Ⅱ号对60例肾综合征出血热内毒素水平进行定量检测，并分析其与病型、肾损、休克、预后的关系，以t检验和X2检验进行统计学分析。结果60例肾综合征出血热病人血浆内毒素水平（190、15±10821Eu·L-1)明显高于对照组(73．47±23．41Eu·L－1），且内毒素血症阳性率高达866％。除恢复期外各期内毒素水平和内毒素血症阳性革也高于对照组，尤以休克期、少尿期、多尿早期升高明显。重型、危重型内毒素水平高于其它临床类型。严重肾损、颅内出血患者内毒素水平显著增高。结论肾综合征出血热患者内毒素水平及内毒素血症阳性率显著增高，并与临床病型、休克发生、肾损严重程度、预后有密切关系。
Objective To investigate the level of plasma endotoxin in patients with hemorrhagic fever with sub syndrome and its role in lesion. Methods The amount of endotoxin in 60 cases of hemorrhagic fever with renal syndrome was detected quantitatively by Tang reagent Ⅱ, and its relationship with type, kidney damage, shock and prognosis was analyzed. The t test and X2 test were used for statistical analysis. Results The plasma endotoxin levels in 60 patients with hemorrhagic fever with renal syndrome (190,15 ± 10821Eu · L-1) were significantly higher than those in the control group (73.47 ± 23.41Eu · L-1), and the positive rate of endotoxemia Up to 866%. Except for the recovery period, the levels of toxins and endotoxemia-positive leathers in each phase were also higher than those in the control group, especially in shock phase, oliguria phase and early polyuria. Heavy, endotoxin levels are higher than other clinical types. Severe renal damage, intracranial hemorrhage endotoxin levels were significantly higher. Conclusions The endotoxin level and the positive rate of endotoxemia in patients with hemorrhagic fever with renal syndrome are significantly increased, which are closely related to the clinical type, the occurrence of shock, the severity of renal damage and the prognosis.