论文部分内容阅读
本文为提高难溶性药物水飞蓟宾的口服吸收,以亚油酸乙酯、聚氧乙烯蓖麻油和聚乙二醇400为处方制备自微乳化给药系统,并对其理化性质和生物利用度进行评价。体外释放实验和分散实验结果表明自微乳化给药系统相对于市售品可显著提高药物溶出和释放速度;体内实验表明,自微乳化给药系统的药时曲线下面积(AUC)和达峰浓度都明显高于市售品,生物利用度为市售品的2.3倍。这些实验结果表明自微乳化给药系统可用于难溶性药物的口服吸收。
In order to improve the oral absorption of silybin, a poorly soluble drug, a self-microemulsifying drug delivery system was prepared by using ethyl linoleate, polyoxyethylene castor oil and polyethylene glycol 400 as a prescription. The physicochemical properties and bioavailability Degree for evaluation. The results of in vitro release experiment and dispersion experiment show that the self-microemulsifying drug delivery system can significantly improve the dissolution and release rate of drugs compared with the commercial products. In vivo experiments show that the area under the curve (AUC) and the peak area of self-microemulsifying drug delivery system Concentrations were significantly higher than the commercial products, bioavailability of 2.3 times the commercial products. These experimental results show that self-microemulsifying drug delivery systems can be used for oral absorption of poorly soluble drugs.