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甘露醇水溶液旋光度很小,无法定量,加硼砂生成络合物比旋度增大,但影响因素较多,本文就此进一步研究,找出最佳条件。 1 测定条件及方法:精称硼砂7.5g,置于50ml容量瓶中,加20％甘露醇25.0ml加热至溶,冷后加水至刻度,用上海产w22自动指示旋光仪测定旋光度,按下式计算含量,C=100·α/L·〔α〕_(25)~D 2 硼砂量对比旋度的影响:取甘露醇注射液9份,分别加不同量硼砂,测其旋光度,结果见表1。甘露醇比旋度随硼
Mannitol aqueous solution of small optical rotation, can not be quantified, borax borax complex than the rotation increases, but more influencing factors, this paper to further study to find out the best conditions. 1 Determination of conditions and methods: Borax known as refined 7.5g, placed in a 50ml volumetric flask, add 20% mannitol 25.0ml heated to dissolve, add water to the mark after cold, with the Shanghai production w22 automatic indicator polarimeter to determine the optical rotation, press Calculated content, C = 100 · α / L · [α] _ (25) ~ D 2 Effect of borax on specific rotation: Take 9 parts of mannitol injection, respectively, with different amounts of borax, measured the optical rotation, the results See Table 1. Mannitol specific rotation with boron