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1例68岁胃恶性间质瘤女性患者术后口服伊马替尼400mg,1次/d。半年后超声心动图示心包少量积液,5年后出现双下肢轻度水肿、心房颤动,超声心动图示心包中等量积液。停用伊马替尼,2周后心包积液减少;3周后心包积液完全消失,且未再发作心房颤动,双下肢水肿明显减轻。再次按照原剂量服用伊马替尼,2周后再次出现少量心包积液,3及6个月时超声心动图均未见心包积液,且未再发作心房颤动。
One case of 68-year-old female gastric malignant stromal tumor was treated with imatinib 400 mg once daily. Six months after echocardiography showed a small amount of fluid pericardial effusion, mild edema of both lower extremities after 5 years, atrial fibrillation, echocardiography showed moderate volume effusion. Disable imatinib, 2 weeks after the pericardial effusion decreased; 3 weeks after pericardial effusion completely disappeared, and no recurrent atrial fibrillation, edema of both lower extremities eased. Imatinib was again taken at the original dose, and a small amount of pericardial effusion appeared again after 2 weeks. No pericardial effusion was observed at 3 and 6 months after echocardiography, and no further episodes of atrial fibrillation were observed.