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山梗碱类生物碱多为2,6位上各有一侧链的哌啶类化合物。本文报道了山梗酮碱(Ⅱ)、去甲山梗酮碱(Ⅲ)、山梗醇碱(Ⅳ)、去甲山梗醇碱(Ⅴ)、2,6-二丙酮基哌啶(Ⅵ),N-甲基-2,6-二丙酮基哌啶(Ⅶ)及2-丙酮基-6-苯甲酰甲基哌啶(Ⅷ)的合成。以苯基锂为催化剂使2-甲基-6-丙酰甲基吡啶的缩酮(Ⅺ)与苯甲醛反应时,缩酮被破坏而得到2-甲基-6-(2,2-二苯基丁基)吡啶(ⅩⅥ)。以氨基钠作为催化剂时,苯甲醛转变为苯甲酰胺。Ⅳ和Ⅴ对呼吸中枢有较强的兴奋作用。
Hill stem alkaloids mostly 2,6 on each side of the chain of piperidine compounds. In this paper, the effects of regiolone (Ⅱ), desferriostemoline (Ⅲ), octopamine alkaloids (Ⅳ), norfloxacin (Ⅴ), 2,6- Synthesis of N-methyl-2,6-diacetonylpiperidine (VII) and 2-acetonyl-6-phenacylpiperidine (VIII) When ketal (XI) of 2-methyl-6-propionylpyridine is reacted with benzaldehyde using phenyllithium as a catalyst, the ketal is destroyed to give 2-methyl-6- Phenylbutyl) pyridine (XVI). With sodium amide as a catalyst, benzaldehyde is converted to benzamide. Ⅳ and Ⅴ have a strong excitement on the respiratory center.