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目的观察TGF-β1、PTEN、p53在不同组织类型胃癌中的表达意义及它们之间的关联性,以探讨胃癌发生发展的可能机制。方法应用免疫组化SP法分别检测不同病理组织类型胃腺癌61例及正常34例胃镜取材组织中TGF-β1、PTEN、p53的表达情况。结果TGF-β1、p53在胃癌组织中的阳性表达明显高于正常胃组织(P<0.05),随着分化程度降低,TGF-β1、p53表达明显增高(P<0.05);PTEN在胃癌组织中的阳性表达明显低于正常胃组织(P<0.05),随着分化程度降低,PTEN表达明显减少(P<0.05)。胃癌组织中TGF-β1与PTEN表达呈负相关(P<0.05),p53与PTEN表达呈负相关(P<0.05),TGF-β1与p53表达呈正相关(P<0.05)。结论TGF-β1、PTEN及p53的表达可能与胃癌的发生发展密切相关,且可能与胃癌生物学行为及预后有关。
Objective To observe the expression of TGF-β1, PTEN and p53 in different types of gastric cancer and the correlation between them, and to explore the possible mechanism of the occurrence and development of gastric cancer. Methods The expressions of TGF-β1, PTEN and p53 in 61 cases of gastric adenocarcinoma and 34 cases of normal gastroscope were detected by SP immunohistochemical method respectively. Results The positive expression of TGF-β1 and p53 in gastric cancer tissues was significantly higher than that in normal gastric tissues (P <0.05). The expression of TGF-β1 and p53 was significantly increased as the differentiation degree decreased (P <0.05) (P <0.05). The expression of PTEN was significantly decreased as the differentiation degree decreased (P <0.05). There was a negative correlation between the expression of TGF-β1 and PTEN (P <0.05), the expression of p53 and PTEN was negatively correlated (P <0.05), and the expression of TGF-β1 was positively correlated with the expression of p53 (P <0.05). Conclusion The expressions of TGF-β1, PTEN and p53 may be closely related to the occurrence and development of gastric cancer, and may be related to the biological behavior and prognosis of gastric cancer.