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目的：探讨急性低压缺氧及急性低压不缺氧对免疫系统的影响并分析其主要因素。方法：小白鼠分为３组，急性低压缺氧５ｋｍ３０ｍｉｎ、急性低压不缺氧５ｋｍ３０ｍｉｎ及地面对照组。实验组在５ｋｍ分别低压缺氧３０ｍｉｎ、低压不缺氧３０ｍｉｎ后，下降至地面，处死。应用３Ｈ－ＴｄＲ掺入法检测淋巴细胞增殖水平，小鼠胸腺细胞增殖法测定ＩＬ－１、ＩＬ－２活性，小鼠骨髓细胞增殖法检测ＩＬ－３活性。结果：急性低压缺氧组与地面对照组或急性低压不缺氧组比较：Ｔ淋巴细胞的增殖反应、ＩＬ－１和ＩＬ－２活性有差异（Ｐ＜０．０５），实验组Ｂ淋巴细胞的增殖反应、ＩＬ－３活性与对照组比较无差异（Ｐ＞０．０５））。结论：５ｋｍ急性低压缺氧３０ｍｉｎ对细胞免疫有抑制作用，对体液免疫无影响。５ｋｍ急性低压不缺氧３０ｍｉｎ对细胞免疫和体液免疫均无影响。表明缺氧是急性低压缺氧对细胞免疫抑制作用的主要因素
Objective: To investigate the effects of acute hypobaric hypoxia and acute hypobaric hypoxia on the immune system and to analyze its main factors. Methods: The mice were divided into 3 groups: acute hypobaric hypoxia 5km30min, acute hypobaric hypoxia 5km30min and ground control group. The experimental group at 5km hypobaric hypoxia 30min, hypobaric hypoxia 30min, down to the ground, sacrificed. The proliferation of lymphocytes was detected by 3H-TdR incorporation, the activity of IL-1 and IL-2 by thymocyte proliferation assay, and the activity of IL-3 by bone marrow cell proliferation assay. Results: Compared with the control group or the acute hypobaric hypoxia group, the acute hypobaric hypoxia group showed the proliferative response of T lymphocytes and the difference of IL-1 and IL-2 activity (P <0.05). In the experimental group, B lymphocytes Proliferative response, IL-3 activity compared with the control group no difference (P> 0.05)). CONCLUSION: Acute hypobaric hypoxia at 5km for 30min has inhibitory effects on cellular immunity and no effect on humoral immunity. 5km acute hypobaric hypoxia 30min had no effect on cellular and humoral immunity. Hypoxia is a major factor in the immunosuppressive effect of acute hypobaric hypoxia