论文部分内容阅读
苯磺酰氯(BSC)是一种无色或淡黄色液体,易溶于有机溶剂,不溶于水。BSC是生产染料,植物保护剂和药品的中间产物。以往主要报导了动物实验的结果。眼、皮肤和牯膜直接接触BSC时有强烈刺激作用。大鼠经口及腹腔给药LD_(50)为1.19g/kg和76mg/kg。从经口给药的毒性看BSC属低毒物质。波兰研究者研究了给致死剂量BSC的动物的病理,认为对内脏没有明显的选择性毒性,并建议BSC车间空气中的最高容许浓度为19.6mg/m~3。豚鼠致敏实验为阳性,因此认为BSC有使人致敏的可能性。通过临床观察,本文作者认为BSC应属强致敏物质。
Benzenesulfonyl chloride (BSC) is a colorless or light yellow liquid that is soluble in organic solvents and insoluble in water. BSC is an intermediate for the production of dyes, plant protection agents and pharmaceuticals. In the past mainly reported the results of animal experiments. Eye, skin and membrane direct contact with BSC have a strong stimulating effect. The LD 50 of rats was 1.19g / kg and 76mg / kg orally and intraperitoneally. BSC is a low-toxic substance from the toxicity of oral administration. Polish researchers studied the pathology of animals given the lethal dose of BSC and found no significant selective toxicity to the gut and recommended a maximum allowable concentration of 19.6 mg / m3 in BSC workshop air. Guinea pig sensitization test is positive, so that BSC has the possibility of sensitization. Through clinical observation, the authors believe that BSC should be strongly sensitized material.