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移植物抗宿主病(ＧＶＨＤ)是造血干细胞移植后的严重并发症之一。ＧＶＨＤ的发生与供体Ｔ细胞的数量有关。近年研究表明带有单纯疱疹病毒胸苷激酶(ＨＳＶｔｋ)基因的Ｔ细胞,既有Ｔ细胞的功能,又对抗病毒感染药物———更昔洛韦(ｇａｎｃｉｃｌｏｖｉｒ,ＧＣＶ)敏感。将带有ｔｋ
Graft-versus-host disease (GVHD) is one of the serious complications after hematopoietic stem cell transplantation. The incidence of GVHD is related to the number of donor T cells. In recent years, studies have shown that T cells bearing the herpes simplex virus thymidine kinase (HSVtk) gene have both the function of T cells and are sensitive to the anti-viral drug ganciclovir (GCV). Will have tk