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认识淋巴细胞有 T-细胞或 B-细胞来源的细胞表面标记之后,对白血病和淋巴瘤已有可能在细胞来源或细胞特征的基础上加以分类。急性淋巴母细胞白血病从其临床表现,对化疗的反应,病程以及预后等方面,长期以来已认为是一种异源性疾病。然而,虽然有这种临床的异质性,但在形态学上二类淋巴母细胞却无法加以区别。自从 Minowada,Ohnuma 和Moope(1972)从一个病人观察到其淋巴细胞有 T-细胞表面标记之后,很多研究者试图了解是否所有儿童型急性淋巴母细胞白血病均表现为 T-细胞的恶性增生。
Recognition of T-cell or B-cell-derived cell surface markers in lymphocytes It has been possible to classify leukemias and lymphomas on the basis of cell origin or cell characteristics. Acute lymphoblastic leukemia has long been considered as a heterologous disease in terms of its clinical manifestations, response to chemotherapy, duration of disease and prognosis. However, despite this clinical heterogeneity, morphological classification of lymphoblasts can not be distinguished. Since Minowada, Ohnuma, and Moope (1972) observed T-cell surface markers of their lymphocytes from one patient, many researchers sought to understand whether all childhood acute lymphoblastic leukemia presents with malignant hyperplasia of T-cells.