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目的探讨梅毒感染不育患者对胚胎发育潜能的影响,为其行体外受精-胚胎移植(IVFET)治疗知情选择提供帮助。方法选取无梅毒感染不孕患者124例纳入对照组;选择梅毒感染不孕患者44例纳入观察组,两组均行IVF-ET治疗,比较两组受精率、卵裂率、优质胚胎率、临床妊娠率、可移植胚胎数、胚胎种植率、临床妊娠率、流产率及生化妊娠率。结果观察组受精率(79.65%)、卵裂率(99.09%)、2PN率(64.53%)、优质胚胎率(62.27%)与对照组的79.27%、98.86%、62.27%、64.30%比较,差异均无统计学意义(P>0.05)但临床妊娠率(42.50%)及胚胎种植率(32.00%)明显低于对照组的61.36%、50.00%,,差异有统计学意义(P<0.05)。结论梅毒患者行IVF-ET治疗时临床妊娠率、胚胎种植率降低,受精形成胚胎后继续发育潜能无显著性差异,故其行IVF-ET治疗前应充分知情同意。
Objective To investigate the influence of infertility patients with syphilis on the embryo development potential and to help them with the informed choice of IVFET treatment. Methods 124 infertile women without syphilis infection were enrolled in the control group. Forty-four patients with syphilis infertility were enrolled in the observation group. IVF-ET was given to both groups. The fertilization rate, cleavage rate, high-quality embryo rate, Pregnancy rate, number of transplantable embryos, embryo implantation rate, clinical pregnancy rate, abortion rate and biochemical pregnancy rate. Results The differences in fertilization rate, cleavage rate (99.09%), 2PN rate (64.53%), high quality embryo rate (62.27%) and 79.27%, 98.86%, 62.27%, 64.30% (P> 0.05). However, the clinical pregnancy rate (42.50%) and embryo implantation rate (32.00%) were significantly lower than those in the control group (61.36%, 50.00%, P <0.05). Conclusion The clinical pregnancy rate and implantation rate of IVF-ET in syphilis patients are decreased, and there is no significant difference in fertility after embryo development. Therefore, patients with syphilis should be fully informed before IVF-ET treatment.