脂联素(adiponectin,APN)是一种专由脂肪细胞分泌的血浆蛋白,其主要是由内脏脂肪组织合成(如大网膜等),而皮下脂肪组织合成相对较少。人APN由244个氨基酸组成,其分子结构可分成3个部分:氨基末端的分泌信号序列,中间的胶原样结构域及羧基末端的球形结构域。其球形结构域的三维结 Adiponectin (APN) is a plasma protein secreted exclusively by adipocytes, which is mainly synthesized by visceral adipose tissue (such as the omentum, etc.), whereas subcutaneous adipose tissue synthesis is relatively small. Human APN consists of 244 amino acids, and its molecular structure can be divided into three parts: the amino-terminal secretion signal sequence, the middle collagen-like domain and the carboxyl-terminal globular domain. The three-dimensional knot of its spherical domain